How much does a box of lemborexant cost?

Author: Medicalhalo

Release time: 2025-10-19 11:44:20

The price of lemborexant

Lemborexant has been launched in Japan, the United States and other regions, but as of December 6, 2023, it has not yet been launched in mainland China. It is currently understood that The Japanese version of Lebrasin is roughly as follows, but the price is not fixed due to various factors:

The price of 10mg*100 tablets is about 165 US dollars;

The price of 5mg*100 tablets is about 117 US dollars;

The price of 2.5mg*100 tablets is about 77 US dollars.

Purchasing channels for lemborexant

You can go to areas where it is already on the market and go to large local hospitals or clinics to inquire whether they can buy lemborexant. It is recommended to purchase it at a local qualified hospital pharmacy with a doctor’s prescription to prevent being deceived.

Online consultation network platform, you can search for Lebrasyn on the websites of relevant domestic professional overseas medical service institutions. It can help patients obtain medicines and can be mailed to their homes. It is guaranteed to be genuine and more cost-effective. However, it requires a qualified and formal platform to avoid being deceived. It is recommended to consult customer service personnel for specific fees and acquisition procedures.

Dosage of lemborexant

The recommended dose of lemborexant is 5 mg, taken no more than once per night before bedtime, with at least 7 hours remaining before the planned awakening time.

Dose may be increased to a maximum of 10 mg based on clinical response and tolerability. If taken with or shortly after a meal, the time to sleep may be delayed.

Do not drink alcohol while taking lemborexant. It increases the chance of serious side effects.

If you take lemborexant and get less than a full night's sleep (at least 7 hours), or if you take more leborexant than your doctor prescribed, do not drive, operate heavy machinery, do anything dangerous, or do other activities that require clear thinking.

You may still feel drowsy the day after taking lemborexant. Do not drive or engage in other dangerous activities until you feel fully awake.

Therapeutic efficacy of lemborexant

A trial evaluated changes in insomnia severity in participants with moderate to severe insomnia (Insomnia Severity Index [ISI] score ≥15) who took nightly lemborexant for 12 months.

This phase 3 randomized study included two 6-month treatment periods. In the first phase, 949 subjects were randomized to receive placebo, 5 mg (LEM5), or 10 mg (LEM10). In Period 2, placebo subjects were rerandomized to LEM5 or LEM10; subjects originally randomized to take continued to receive their assigned treatment. Insomnia severity was assessed by baseline ISI and scores at 1, 3, 6, 9, and 12 months after treatment.

Results showed

The LEM5 and LEM10 groups experienced greater decreases in mean ISI scores from baseline at month 1 (-7.1, -7.2, -5.2, respectively), month 3 (-8.6, -8.9, -8.5), month 12, and month 12 compared with the placebo group. 6, -8.9, -6.1) and 6 months (-9.9, -9.8, -7.2, respectively); LEM5 and LEM10 maintained improvements in ISI scores at 9 months (-11.1 and -11.2, respectively) and 12 months (-11.5 and -11.2, respectively).

Significantly more treatment responders (≥7-point decrease in ISI score from baseline) were seen in LEM5 (44%-57%) and LEM10 (44%-52%) than placebo (30%-41%) at months 1, 3, and 6. At 1, 3, and 6 months, there were more responders (ISI total score <10 and <8) in LEM5 (30%-44% and 22%-34%, respectively) and LEM10 (31%-41% and 22%-31%, respectively) compared with placebo (18%-28% and 11%-21%, respectively).

Trial Conclusion

Compared with placebo, taking lemborexant can significantly reduce the severity of insomnia within 12 months and increase clinically meaningful response and remission rates.

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