Remedygipan indications, efficacy and effects, usage and dosage, efficacy, side effects, precautions, price

Dosage Forms and Specifications

Orally disintegrating tablets: white to off-white round tablets, debossed with symbols, each tablet contains 75 mg of remijipan.

Drug ingredients

1. Active ingredient: Remedypan.

2. Inactive ingredients: benzyl alcohol, eucalyptol, gelatin, limonene, mannitol, menthol, sucralose and vanillin, menthone, menthyl acetate.

Indications

1. Migraine: Acute treatment of migraine with or without aura in adults.

2. Preventive treatment of episodic migraine.

1. Acute treatment of migraine: The recommended dose is 75mg. Take it as needed. The maximum dose within 24 hours is 75mg.

2. Preventive treatment of episodic migraine: The recommended dose is 75 mg, taken orally every other day.

Efficacy and effects

It is a small molecule inhibitor of the calcitonin gene-related peptide (CGRP) receptor, which blocks the effect of CGRP, which is a potent vasodilator and is thought to play a role in migraine.

Remegipan mainly relieves migraine symptoms by inhibiting the activation of 5-HT1F receptors on nerve receptors and reducing the function of this receptor. The main function and function of Remedipan is to relieve headache, drowsiness, nausea and other symptoms during migraine attacks. It not only effectively relieves the pain and discomfort of migraines, but also helps reduce frequent migraine attacks and improve the patient's quality of life.

Efficacy

Research Background

Rimegepant has shown efficacy and safety in the acute treatment of migraine. This study was designed to compare the efficacy of Rimegepant with placebo in the preventive treatment of migraine.

Research Methods

In a multicenter, phase 2/3, randomized, double-blind, placebo-controlled trial, 747 adults with a history of at least 1 year of migraine were recruited to receive 75 mg of remegipan (n=373) or placebo (n=374) orally every other day.

Results

Remagepam was superior to placebo in the change in mean number of migraine days per month between weeks 9-12. Between weeks 9 and 12, the change in mean number of migraine days per month was -4±3 days for those taking remagepam and -3±5 days for those taking placebo.

A statistically significantly higher percentage of patients who received remagepam achieved headache pain relief and MBS relief within two hours of a single dose compared to patients who received placebo.

Side effects and treatment measures

The common ones are nausea, abdominal pain, and indigestion.

1. Nausea: You should choose light, easy-to-digest foods, such as egg custard, etc. Avoid eating spicy and irritating foods such as chili peppers, spicy hot pot, barbecue, etc., and do not eat overly greasy foods such as fatty meats. Eat small and frequent meals in moderation, avoid overeating, drink more warm water in moderation, and try to avoid alcohol.

2. Abdominal pain: It is recommended to stop eating, rest in a comfortable position, and gently massage the abdomen to relieve pain. You can take acetaminophen, naproxen, nabumetone, indomethacin, ibuprofen and other drugs as directed by your doctor. Do not engage in strenuous exercise when you are too full or hungry.

3. Indigestion: Avoid ingesting high-fat foods or alcohol, strong tea, coffee, etc., and try to avoid using drugs that can irritate the gastric mucosa. Develop good living and eating habits, eat three meals at regular intervals and avoid overeating.

Precautions

Allergic reactions, including dyspnea and rash, may occur when taking Mejipan. If an allergic reaction occurs, you should stop using Mejipan immediately and start professional anti-allergy treatment.

Drug interactions

1. Strong or moderate CYP3A4 inhibitors: Avoid taking remegipan and strong CYP3A4 inhibitors at the same time. When coadministered with a moderate inhibitor of CYP3A4, avoid taking another dose of remagepam within 48 hours.

2. Strong or moderate CYP3A inducers: Avoid coadministration of remagepam with strong or moderate CYP3A inducers, which may result in the loss of remagepam's efficacy.

Price

1. Hong Kong version of Ruimei Jipan: 75mg*8 tablets. The current reference price is about 2700$ per box.

2. Biohaven Pharmaceutical's Remedypan: 75mg*8 tablets. The current reference price is about $11,500 per box.

Contraindications

It is contraindicated if you are allergic to Remedil or any of its components.

Storage Conditions

Store Remedigen at controlled room temperature of 20-25°C (68°F-77°F), with a tolerance of 15-30°C (59-86°F).

Usage for Special Populations

1. Breastfeeding women: The developmental and health benefits of breastfeeding should be considered, as well as the mother’s clinical need for Remijipan.

2. Pediatric patients: The safety and effectiveness of the drug have not yet been determined.

3. Patients with liver damage: Patients with mild or moderate hepatic impairment do not need to adjust the dose of Remedipam, and patients with severe liver impairment should avoid taking Remedipam.

4. Patients with renal impairment: Patients with mild, moderate or severe renal impairment do not need to adjust the dose of remegipan.

References:

Croop R, Lipton RB, Kudrow D, Stock DA, Kamen L, Conway CM, Stock EG, Coric V, Goadsby PJ. Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomized, double-blind, placebo-controlled trial. Lancet. 2021 Jan 2;397(10268):51-60. doi: 10.1016/S0140-6736(20)32544-7. Epub 2020 Dec 15. PMID: 33338437.

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