港版氢化可的松片安全性高吗

It is a commonly used glucocorticoid drug in clinical practice. Its molecular structure is close to the corticosteroids synthesized by the body itself, and it can exert anti-inflammatory, anti-shock, anti-allergic, anti-toxin, immune-suppressing and other effects without being metabolized by the liver.

A total of 6 studies were included, with a total of 2374 patients included, including 1194 in the experimental group and 1180 in the control group. Meta-analysis results show that in terms of effectiveness, the combined use of hydrocortisone and fludrocortisone can reduce the 28-day mortality rate [RR=0.87, 95% CI (0.77, 0.98), P=0.02] and the intensive care unit (ICU) mortality rate [RR=0.87, 95% CI (0.78, 0.97)] compared with the control group. , P=0.01]. In-hospital mortality rate [RR=0.89, 95%C (0.81, 0.97), P=0.01], the difference is statistically significant. In terms of safety, hydrocortisone combined with fludrocortisone will not increase the rate of gastroduodenal bleeding [RR=0.98, 95% CI (0.68, 1.41), P=0.90] or re-infection rate [RR=1.09, 95% CI (0.93, 1.27), P=0.28], and the difference is not statistically significant.

Evidence shows that hydrocortisone combined with fludrocortisone in the treatment of adult septic shock can reduce the patient's 28-day mortality, ICU mortality, and hospitalization mortality without increasing the risk of gastroduodenal bleeding and superinfection, and is highly safe.

Its pharmacological characteristics are short half-life, rapid absorption, and rapid onset of action. The drug's action time is generally 8 to 12 hours. It has no obvious inhibitory effect on the HPA axis and no obvious adverse reactions of raising blood sugar.