氢化可的松片对肾上腺皮质增生症有多大的疗效？

For glucocorticoid drugs. It has various pharmacological effects such as anti-inflammatory, anti-toxic, anti-shock and immunosuppressive effects. 1 Anti-inflammatory effect: It has an effect on inflammation caused by various causes except viruses. Glucocorticoids can reduce and prevent tissue responses to inflammation, thereby alleviating the symptoms of inflammation. They can also inhibit the repair of tissues in the later stages of inflammation and reduce sequelae. 2 Immunosuppressive effects: Prevent or inhibit cell-mediated immune responses, delayed allergic reactions, and reduce the expansion of primary immune responses. 3 Anti-toxic and anti-shock effects: Glucocorticoids can improve the body's tolerance, reduce cell damage, and play a role in protecting the body. It also dilates blood vessels, enhances myocardial contractility, and improves microcirculation.

To explore the application and efficacy of two oral hormones, hydrocortisone and prednisone, in postoperative hormone replacement therapy in patients with hypercortisolism. 60 patients with hypercortisolism admitted to the hospital from January 2016 to December 2016 were selected and randomly divided into two groups, A and B, with 30 cases in each group.

On the day after surgery and the first day after surgery, all patients were given intravenous infusion of 100 mg hydrocortisone, and then another infusion 12 hours later. On the second day after surgery, group A started taking oral hydrocortisone acetate tablets, and group B started taking oral prednisone acetate tablets.

result (1) The two groups of patients did not show adrenocortical insufficiency during hormone replacement therapy. The average drug withdrawal time in group A was (6.61±1.25) months, and the average drug withdrawal time in group B was (4.90±1.06) months; (2) After surgery, the patients in groups A and B The blood and urine Cor levels were significantly lower than those in the same group before surgery (P0.05), and there was no statistically significant difference between the groups; (3) The postoperative serum sodium and serum potassium levels of patients in groups A and B were significantly lower than those before surgery in the same group (P0.05), and there was no statistically significant difference between the groups. It can be seen that the effect is still very good.