Is hydrocortisone treatment effective?

The main component of this drug is hydrocortisone acetate, which is an adrenocortical hormone drug. This drug can be used clinically as an alternative treatment for adrenal insufficiency, and it also has a certain therapeutic effect on congenital adrenal hyperplasia. For patients taking this drug, they should go to the hospital and consult a doctor before choosing hydrocortisone treatment. They must strictly follow the doctor's instructions when using the drug, and do not adjust the dosage on their own.

Is hydrocortisone treatment effective? The trial explores the application and efficacy of two oral hormones, hydrocortisone and prednisone, in postoperative hormone replacement therapy in patients with hypercortisolism.

The clinical trial selected 60 patients with hypercortisolism and randomly divided them into two groups, with 30 patients in each group. All patients were given intravenous infusion of 100 mg hydrocortisone on the day after surgery and the first day after surgery, and then another infusion 12 hours later. On the second day after surgery, group A started taking oral hydrocortisone, and group B started taking oral prednisone tablets.

result It showed that (1) the two groups of patients did not experience adrenocortical insufficiency during hormone replacement therapy. The average drug withdrawal time in the hydrocortisone group was (6.61±1.25) months, and the average drug withdrawal time in the prednisone group was (4.90±1.06). months; (2) the postoperative blood and urine Cor levels of the two groups of patients were significantly lower than those of the same group before surgery, and there was no statistically significant difference between the two groups; (3) the postoperative blood sodium and serum potassium levels of the two groups of patients were significantly lower than those of the same group before surgery (P0.05), and there was no statistically significant difference between the two groups.

The conclusion shows that oral corticosteroids and prednisone are safe and effective in postoperative hormone replacement therapy in patients with hypercortisolism.