依普利酮安全性怎么样？

It is produced by Lupine Pharmaceuticals in India and is suitable for essential hypertension and heart failure after myocardial infarction. For severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of eplerenone can significantly reduce blood pressure, especially the decrease in systolic blood pressure is more significant. So, what is the safety of India’s Lupine Pharmaceuticals’ eplerenone?

Studies have shown that eplerenone can cause a sustained increase in plasma renin and serum aldosterone, and at the same time block the feedback regulatory effect of aldosterone. However, the increase in plasma renin activity and the increase in systemic circulation aldosterone levels will not offset the blood pressure control effect of this product.

Eplerenone and spironolactone work on the same principle. Long-term use of spironolactone can cause endocrine disorders, while eplerenone has good tolerance and has the advantage of less side effects, avoiding the side effects of endocrine disorders.

Eplerenone treats patients with stage 1 and stage 2 hypertension with similar efficacy rates and reductions in systolic and diastolic blood pressure as enalapril. Eplerenone also has a good antihypertensive effect in patients with essential hypertension with low renin levels for whom angiotensin-converting enzyme inhibitors and angiotensin II receptor inhibitors are not effective.

It also has a good antihypertensive effect on simple systolic hypertension, and has a good antihypertensive effect on diet-induced obesity-related hypertension. In addition, eplerenone can significantly reduce the ultrafiltration effect of glomeruli and reduce albuminuria in patients with hypertension. This renal protective effect is more obvious for hypertensive patients with diabetes.

Lupine Limited is an Indian multinational pharmaceutical company. Eplerenone has not yet been launched in the country, and there is no talk of medical insurance.

Eplerenone is the first selective aldosterone receptor antagonist and has been used to treat hypertension and left ventricular dysfunction after acute myocardial infarction. It can effectively lower blood pressure, improve cardiac function, and reduce myocardial damage.

It is a selective aldosterone receptor antagonist, which only acts on mineralocorticoid receptors and does not act on androgen and progesterone receptors, and has fewer side effects.