依普利酮去哪买？

It is a selective aldosterone receptor antagonist, which only acts on mineralocorticoid receptors and does not act on androgen and progesterone receptors, and has fewer side effects. Eplerenone is an oral drug with definite efficacy in the treatment of hypertension, heart failure and myocardial infarction. So, where can I buy eplerenone from Lupine Pharmaceuticals in India?

Lupine Limited is an Indian multinational pharmaceutical company. Eplerenone has not yet been launched in China, and there is no medical insurance. Planep 50mg*100 tablets are priced at about $500 per box. Patients in need can purchase medicines abroad or obtain medicines through domestic professional overseas medical service organizations (such as Medical Companion Travel), which can be delivered directly to their homes to ensure authenticity.

Eplerenone selectively acts on aldosterone receptors and is highly selective for mineralocorticoid receptors, but has less effect on androgen and progesterone receptors. Its affinity for mineralocorticoids is 15 to 20 times that of spironolactone, while its affinity for androgen and progesterone receptors is 500 times smaller than that of spironolactone, so sex hormone-related adverse reactions are less likely to occur.

In a study of systolic hypertension in the elderly, 269 patients were treated with eplerenone (50-200) mg daily and amlodipine (2.5-10) mg daily. The results showed that both drugs had the same effect in lowering systolic blood pressure, while amlodipine lowered diastolic blood pressure more significantly.

In terms of target organ protection, both drugs improved carotid-femoral and carotid-radial pulse rates after 24 weeks of treatment. In terms of the incidence of adverse reactions, 19.9% ​​of the amlodipine group developed peripheral edema, while only 2.7% of the eplerenone group developed hyperkalemia. 0.4% of the amlodipine group developed hyperkalemia, and 0.9% of the eplerenone group developed hyperkalemia.

It was approved for clinical use by the State Food and Drug Administration in 2002, but it has not been marketed in China, so Chinese patients cannot currently buy this drug in domestic pharmacies.