依普利酮在治疗高血压这方面的效果怎么样？

(Alias: Planep) is a new type of selective aldosterone receptor antagonist that was approved for clinical use by the my country Food and Drug Administration in 2002.  

Eplerenone (alias: Planep) has a stronger aldosterone antagonism than spironolactone, and has extremely low sensitivity to androgens and luteal copper protein kinase. It has little side effects and is effective in treating hypertension, heart failure and myocardial infarction. It has fewer side effects and good tolerance. It is an excellent substitute for spironolactone. How effective is eplerenone in treating hypertension?

To explore the clinical value of Losartan and Eplerenone (alias: Planep) in the treatment of hypertension.  

A total of 116 patients with mild and moderate hypertension who were treated in the hospital from February 2010 to February 2012 were selected and randomly divided into group A and B, 58 patients each. Group A was treated with eplerenone tablets (alias: Planep), and group B was treated with losartan potassium tablets. Results After treatment, the total effective rate of group A was 91.38%, which was significantly higher than that of the control group, 89.66% (P>0.05).

At the same time, the systolic blood pressure and diastolic blood pressure of the patients in both groups were significantly lower than before treatment (P<0.05); however, there was no significant difference in the systolic blood pressure and diastolic blood pressure between the two groups (P>0.05). At the same time, the monthly decreases in systolic blood pressure and diastolic blood pressure of patients in each group were compared, and the differences were not statistically significant (P>0.05). Patients in both groups experienced serious adverse reactions. There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).  

The main adverse reactions of eplerenone include: cough, diarrhea, abdominal pain, angina, myocardial infarction, proteinuria, headache, dizziness, fatigue, flu-like symptoms, etc.

Conclusion: Losartan and (alias: Planep) can effectively improve patients' blood pressure in the treatment of moderate and mild hypertension without serious adverse reactions, and have clinical application value.

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