依普利酮的治疗效果

Subgroup analysis of the EPHESUS study showed that the effect on reducing overall mortality was more pronounced in patients with hypertension. A comparative study on the efficacy and tolerability of 499 patients with grade 1 or 2 hypertension who were randomized to receive enalapril or eplerenone showed that at 6 months, enalapril was as effective as eplerenone (Inspra) in reducing systolic blood pressure (eplerenone decreased by 14.5 mmHg; enalapril decreased by 12.7 mmHg; P=0.199) and diastolic blood pressure (eplerenone decreased by 11.2 mmHg; enalapril decreased by 11.3 mm). Hg; P=0.910). After 12 months, the two groups were also similar (eplerenone -16.5/-13.3mmHg; enalapril -14.8/-14.1mmHg, P values ​​0.251 and 0.331 respectively).

About 2/3 of the patients in each group achieved normal blood pressure at 6 months with the above single treatment. In the eplerenone group, the reduction in blood pressure was independent of renin levels, unlike enalapril. Both groups could reduce proteinuria above normal levels, but the eplerenone group was more significant (-61.5% vs -25.7%; P=0.01).

It can be seen that eplerenone (Inspra) not only has a significant effect on the treatment of hypertension, but also plays a very good role in reducing proteinuria, making it a good choice for patients with hypertension.

The price of original drugs in the United States is relatively high. The specifications are 50mg-30 tablets/box, and the price is about 124.09 US dollars. The price is very expensive, so many patients can only focus on generic drugs. As far as Medical Travel knows, the price of eplerenone 50mg 100 tablets from India's Lupine Pharmaceuticals is about $500. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.