依普利酮从哪里买

Binds to mineralocorticoid receptors and inhibits the binding of aldosterone (hormone of the renin-angiotensin-aldosterone system (RAAS)). Aldosterone binds to mineralocorticoid receptors in epithelial tissues such as the kidneys and non-epithelial tissues such as the heart, blood vessels, and brain and increases blood pressure through sodium reabsorption and other mechanisms. Eplerenone is thought to exert its antihypertensive effects by inhibiting the effects of these aldosterone. Because eplerenone inhibits the negative feedback of aldosterone on renin secretion, it continuously increases plasma renin activity and plasma aldosterone concentration, but these increases do not mitigate the effects of eplerenone.

Eplerenone shows sustained antihypertensive effects on systolic blood pressure in unilateral nephrectomized hypertensive rats with continuous aldosterone administration/salt loading. Eplerenone showed sustained antihypertensive effects on systolic blood pressure during a 2-week dosing period in stroke-prone spontaneously hypertensive rats (SHRSP). The antihypertensive effect of ACE inhibitors is significantly enhanced when combined with lisinopril. In Dahl salt-sensitive rats, a salt-sensitive low-renin hypertension animal model, eplerenone showed a dose-dependent antihypertensive effect on systolic blood pressure after continuous administration for 4 weeks.

Currently, it is only available in the United States and Japan. China has not yet been approved for marketing. Patients who want to purchase this drug must go abroad to purchase it themselves, or find domestic and overseas medical institutions to purchase it. It is understood that the price of the original drug eplerenone in the United States is relatively high. The specifications are 50mg-30 tablets/box, and the price is about 124.09 US dollars. The price is very expensive, and many patients say they cannot afford it. But luckily, there are also generic versions of this product in India, which have the same efficacy and are affordable. According to Medical Travel, we learned that the price of eplerenone 50mg 100 tablets from India's Lupine Pharmaceuticals is about $500. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.