降压药依普利酮的功效

It is a selective aldosterone receptor antagonist and can be used clinically to treat heart failure and hypertension. If it is to treat heart failure, it is relatively suitable for patients with left ventricular hypertrophy and left ventricular ejection fraction less than or equal to 40%. It can improve the quality of life and prognosis of such patients. If it is to treat high blood pressure, it can be used alone or in combination with other antihypertensive drugs to treat high blood pressure. For patients with heart failure after myocardial infarction, generally speaking, the initial dosage is 25 mg, once a day, and the dosage can be gradually increased. For example, within four weeks, it can be increased to 50 mg, once a day orally according to the patient's actual condition. If it is used to treat hypertension, it is recommended that the initial dose is 50 mg, taken orally once a day. Depending on the improvement of the patient's blood pressure, if the improvement is not obvious, it can be increased to 50 mg, taken orally twice a day.

It is a selective aldosterone receptor antagonist that only acts on mineralocorticoid receptors and does not act on androgen and progesterone receptors. Eplerenone treats patients with stage 1 and stage 2 hypertension with similar efficacy rates and reductions in systolic and diastolic blood pressure as enalapril. Eplerenone also has a good antihypertensive effect in patients with essential hypertension with low renin levels for whom angiotensin-converting enzyme inhibitors and angiotensin II receptor inhibitors are not effective. It also has a good antihypertensive effect on simple systolic hypertension, and has a good antihypertensive effect on diet-induced obesity-related hypertension. In addition, eplerenone can significantly reduce the ultrafiltration effect of glomeruli and reduce albuminuria in patients with hypertension. This renal protective effect is more obvious for hypertensive patients with diabetes.