依普利酮上市后的价格

In 2002, eplerenone was first launched in the United States and is mainly used clinically to treat hypertension.

In 2003, the FDA approved eplerenone for the treatment of heart failure after acute myocardial infarction. So what is the price of eplerenone after it is launched?

Price of eplerenone: It is understood that the price of eplerenone abroad is relatively high, and many patients cannot bear the cost for a long time. What is worth telling everyone is that a box of 50mg × 100 tablets of eplerenone from India's Lupine Pharmaceuticals costs about $500. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

Eplerenone is a selective aldosterone receptor antagonist that can be used clinically to treat heart failure and hypertension.

If it is to treat heart failure, it is relatively suitable for patients with left ventricular hypertrophy and left ventricular ejection fraction less than or equal to 40%. It can improve the quality of life and prognosis of such patients.

If it is to treat high blood pressure, it can be used alone or in combination with other antihypertensive drugs to treat high blood pressure.

For patients with heart failure after myocardial infarction, generally speaking, the initial dosage is 25 mg, once a day, and the dosage can be gradually increased. For example, within four weeks, it can be increased to 50 mg, once a day orally according to the patient's actual condition.

If it is used to treat hypertension, it is recommended that the initial dose is 50 mg, taken orally once a day. Depending on the improvement of the patient's blood pressure, if the improvement is not obvious, it can be increased to 50 mg, taken orally twice a day.

Precautions for eplerenone:

Eplerenone should not be combined with potassium supplements, potassium-containing salts, or contraindicated drugs (potassium-sparing diuretics, strong inhibitors of CYP450 liver enzymes).

Non-steroidal anti-inflammatory drugs and lithium can affect the plasma concentration of eplerenone and affect its efficacy.

Patients with high serum potassium, type 2 diabetes patients with microalbuminuria, patients with high serum creatinine levels, and patients with muscle anesthesia clearance <50 mL/min should not take eplerenone.