Inspra中文的说明书

Chinese instruction manual

[Drug name] eplerenone, eplerenone, Planep

【Inspra indications】

1. Congestive heart failure after acute myocardial infarction: Inspra can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that this product can also be used for heart failure after acute myocardial infarction and congestive heart failure after acute myocardial infarction;

2. Anti-hypertension: Inspra can be used alone or in combination with other anti-hypertensive drugs for the treatment of hypertension.

[Inspra usage and dosage]

1. Congestive heart failure after acute myocardial infarction: The recommended dose is 50 mg/time, once a day. The initial dose should be 25 mg/time, once a day. Within 4 weeks, the dose should be gradually increased to 50 mg/time, once a day, as tolerated by the patient.

2. Anti-hypertensive: Inspra can be used alone or in combination with other anti-hypertensive drugs. The recommended initial dose for use alone is 50 mg once daily. Obvious pressure-reducing effect will appear within four weeks of taking the medicine. If the pressure effect is not obvious, it can be increased to 50mg/time, once a day. Higher dosages are not recommended, otherwise there is an increased risk of adverse reactions such as hyperkalemia.

[Adverse reactions of Inspra] The main adverse reactions are: cough, diarrhea, abdominal pain, angina, myocardial infarction, proteinuria, headache, dizziness, fatigue, flu-like symptoms, etc.

Other adverse reactions include: gynecomastia, abnormal vaginal bleeding; increased levels of serum potassium, triglycerides, cholesterol, alanine aminotransferase, γ-glutamyl transferase, creatinine, and uric acid, and decreased serum sodium levels.

[Notes on Inspra]

1. Inspra cannot be combined with potassium supplements, potassium-containing salts or contraindicated drugs (potassium-sparing diuretics, strong inhibitors of CYP450 liver enzymes).

2. Non-steroidal anti-inflammatory drugs and lithium can affect the blood concentration of Inspra and affect its efficacy.

3. People with high serum potassium, type 2 diabetes patients with microalbuminuria, high serum creatinine levels, and muscle intoxication clearance <50 mL/min should not take it. Pregnant women, children, and those with hepatic and renal insufficiency should use with caution.