eplerenone的适应症有什么？

It is a new generation of selective aldosterone antagonist, developed by Pfizer, and first launched in the United States in 2002 under the trade name Inspra. Eplerenone is indicated for the treatment of congestive heart failure after acute myocardial infarction and is also used to treat hypertension. Eplerenone is a good medicine for the treatment of hypertension, and can also be used as a medicine for myocardial ischemia and chronic myocardial insufficiency. It can protect the liver, heart disease, and kidneys without damaging the organs, and can promote urination without losing potassium.

Endocrine and metabolic side effects of eplerenone that have >10% are: hyperkalemia ([heart failure, post-myocardial infarction: >5.5 meq/L: 16%; ≥6 meq/L: 6%, [hypertension, >5.5 meq/L: 400 mg: 9%; doses ≤200 mg: ≤1%]), hypertriglyceridemia (1%-15%; dose related). 1%-10% of side effects: Central nervous system: dizziness, fatigue, endocrine and metabolic: hyponatremia (2%; dose-related), proteinuria, gynecomastia, hypercholesterolemia; gastrointestinal tract: diarrhea, abdominal pain; genitourinary system: abnormal vaginal bleeding (≤2%), mastalgia (men: ≤1%); kidney: increased serum creatinine (heart failure, post-myocardial infarction: 6%); respiratory system: cough, flu-like symptoms. Symptoms of angioedema, increased blood urea nitrogen, increased liver enzymes, increased uric acid, and rash may occur in <1% of cases.

The recommended dose for the treatment of adults with congestive heart failure is an initial dose of 25 mg orally once daily; gradually increase to the target dose within 4 weeks as tolerated by the patient. Target dose: 50 mg, taken orally, once a day; Common dose for treating hypertension in adults: It can be used alone or in combination with other antihypertensive drugs. Initial dose: 50 mg orally once daily; Maintenance dose: 50 mg orally once or twice daily; Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.