依普利酮价格

(eplerenone) is the first selective aldosterone receptor antagonist. It has been used to treat hypertension and left ventricular dysfunction after acute myocardial infarction. It can effectively lower blood pressure, improve cardiac function, and reduce myocardial damage. The chemical formula of eplerenone (EPL) is 9,11-epoxy-17-hydroxy-3-oxo-γ-lactone-4-pregnene-7,21-dicarboxylic acid methyl ester.

Aldosterone is a corticosteroid secreted by the human body, which promotes the absorption of sodium ions and the excretion of potassium ions, and regulates the composition of electrolytes in the body. However, too much aldosterone can lead to myocardial fibrosis and congestive heart failure. Eplerenone is a highly selective aldosterone receptor antagonist that inhibits hyperaldosteronism.

Eplerenone treats patients with stage 1 and stage 2 hypertension with similar efficacy rates and reductions in systolic and diastolic blood pressure as enalapril. Eplerenone also has a good antihypertensive effect in patients with essential hypertension with low renin levels for whom angiotensin-converting enzyme inhibitors and angiotensin II receptor inhibitors are not effective. It also has a good antihypertensive effect on simple systolic hypertension, and has a good antihypertensive effect on diet-induced obesity-related hypertension. In addition, eplerenone can significantly reduce the ultrafiltration effect of glomeruli and reduce albuminuria in patients with hypertension. This renal protective effect is more obvious for hypertensive patients with diabetes.

It was developed by Pfizer of the United States and first launched in the United States in 2002. It is mainly used clinically to treat hypertension. In 2003, it was approved by the FDA for the treatment of heart failure after acute myocardial infarction. Eplerenone is not yet on the market in my country, so we have no way of knowing the domestic price. Medical Travel learned that in 2019, the price of eplerenone 25mg-30 tablets/box in the United States was around US$118.71. However, the price of eplerenone 50mg*100 tablets from India's Lupine Pharmaceuticals is around RMB 500, which is very cheap. Patients can purchase it through Medical Companion Travel.