维利西呱多少钱一盒?在哪里购买?

Veliciguat is an innovative drug for the treatment of heart failure. Its price varies depending on its specifications and origin. The German original version is more expensive, the Japanese version is relatively economical, and the Chinese version has been included in medical insurance. Understanding purchasing channels and pharmacokinetic properties is of great significance to patients' rational use of drugs. This article will introduce in detail the price information, purchasing methods and pharmacokinetic characteristics of Veliciaguat.

How much does a box of Vilicigua cost?

The price varies significantly depending on the origin, specifications and packaging. The main global circulation versions include the German original version, the Japanese version and the Chinese version, each with a different price system.

Price of the German version

The original drug of Veliciguat produced by Bayer in Germany has different prices in different specifications. The price of 2.5mg*28 tablets is about US$343, while the price of 5mg*98 tablets is about US$640; the price of 10mg*98 tablets is about US$644.

Japanese version price

The Japanese version of Vericiguat is available in 3 specifications. The price of 2.5mg*100 pills is approximately US$151 per box; the price of 5mg*100 pills is approximately US$254 per box; and the price of 10mg*100 pills is approximately US$413 per box.

Price information may fluctuate with the exchange rate. The above prices are for reference only. It is recommended to check the latest pricing before purchasing.

Where to buy Veliciguat

Veliciguat is a prescription drug that needs to be purchased through formal medical channels. The purchasing methods vary in different regions.

Hospital channels

Patients can purchase Vericiguat at the cardiology department or cardiovascular specialty pharmacy of the hospital with a prescription, and can take the medicine directly under the guidance of a doctor.

Pharmacy channel

Some large chain pharmacies can provide Vericiguat, but a valid prescription is required. Non-medical insurance designated pharmacies need to pay the full amount out of their own pocket.

Purchase from medical service institutions

The German or Japanese version can be purchased through formal medical service institutions, and a prescription and proof of identity are required.

Please look for the drug approval number when purchasing to avoid counterfeit products.

Pharmacokinetics of vericiguat

Understanding the pharmacokinetic properties of vericiguat can help optimize the medication regimen. The drug has unique metabolic characteristics.

Absorption and Distribution

The bioavailability reaches 93% when taken with food, and the plasma protein binding rate is 98%. High-fat diet can increase the AUC of 10 mg tablets by 44%.

Metabolism and elimination

Mainly metabolized by UGT1A9/1A1 enzyme, with a half-life of about 30 hours. 53% is excreted in urine and 45% is excreted in feces.

Usage in special populations

The exposure of patients with renal impairment increases by 5-20%, and the exposure of patients with moderate hepatic impairment increases by 47%. No dosage adjustment is required for elderly patients.

Pharmacokinetic data support a once-daily dosing regimen, and administration with food may improve absorption stability.