氯法齐明用法用量是怎样的？有什么副作用？

Clofazimine interferes with the nucleic acid metabolism of leprae bacteria, binds to its DNA, inhibits DNA-dependent RNA polymerase, prevents RNA synthesis, thereby inhibiting bacterial protein synthesis and exerting its antibacterial effect. It is mainly used for the treatment of leprosy. It not only has a slow bactericidal effect on Mycobacterium leprae, but is also effective on Mycobacterium tuberculosis and Mycobacterium ulcerans. In addition, it also has an anti-inflammatory effect.

So, what is the dosage of clofazimine?

Clofazimine is used together with other drugs to treat leprosy, and the dosage varies depending on the condition. For the treatment of various types of dapsone-resistant leprosy, take orally, 50 to 100 mg once a day, in combination with one or several other anti-leprosy drugs; for drug-resistant tuberculosis and non-tuberculous mycobacteria, take 100 mg each time, three times a day, in combination with anti-tuberculosis drugs Combined application of drugs; treatment of multibacillary leprosy: clofazimine, 300 mg, once a month, supervised administration, and 50 mg daily, self-administration, combined with rifampicin and DDS to form a combined chemotherapy regimen, with a course of treatment of at least 2 months, or until the skin smear turns negative for bacteria. Patients need to follow the doctor's instructions when taking medication, because arbitrarily increasing or reducing the dosage of the drug may cause adverse drug reactions. It is recommended that patients read the instructions carefully before taking the medication.

So, what are the side effects of clofazimine?

Patients have different physical constitutions and different side effects. The common side effects of clofazimine are mainly skin redness and pigmentation, which can gradually subside after stopping the drug. Dry skin and ichthyosis-like changes, nausea, vomiting, anorexia, abdominal pain, constipation, diarrhea, drowsiness, dizziness, insomnia, etc. are also side effects of this product. Patients should note that this drug is contraindicated in patients who are allergic to clofazimine; in addition, this drug is also contraindicated in patients with severe liver and kidney dysfunction and gastrointestinal diseases.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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