枢丹在国内有吗？

Is Shudan available in China? Ondansetron hydrochloride is available in China. It is recommended that patients go to the local hospital for consultation. Shudan is a prescription drug. To purchase Shudan, patients need a prescription issued by a doctor.

Shudan (ondansetron hydrochloride) white or off-white tablets are powerful and highly selective 5-HT3 receptor antagonists with strong antiemetic effects. Chemotherapy drugs and radiotherapy, which have strong antiemetic effects, can cause the release of 5-HT in the small intestine and activate the afferent branch of the vagus nerve through 5-HT3 receptors, triggering the vomiting reflex. This product can block this reflex and trigger the afferent branch of the vagus nerve. It can also cause the release of 5-HT in the Postrema area at the bottom of the fourth ventricle, thereby strengthening the nausea and vomiting caused by chemotherapy and radiotherapy through the central mechanism.

Shudan is used for vomiting caused by highly emetic chemotherapy drugs: Inject 8 mg of ondansetron injection intravenously 15 minutes before chemotherapy and 4 hours and 8 hours after chemotherapy. After stopping chemotherapy, take 8 mg of ondansetron tablets orally every 8 to 12 hours for 5 days.

Shudan is used for vomiting caused by chemotherapy drugs that are not very strong in vomiting: Ondansetron injection 8 mg is injected intravenously 15 minutes before chemotherapy, and then 8 mg ondansetron tablets are taken orally every 8 to 12 hours for 5 days.

Shudan is used for vomiting caused by radiotherapy: the first dose must be taken orally as a tablet of 8 mg 1 to 2 hours before radiotherapy, and then 8 mg orally every 8 hours. The course of treatment depends on the course of radiotherapy.

Shudan is used to prevent nausea and vomiting after surgery: take 8 mg tablet orally 1 hour before anesthesia and then take 8 mg tablet orally twice every 8 hours.

Oral administration (ondansetron hydrochloride) reaches peak plasma concentration in about 2 hours, and its bioavailability is approximately 60% (higher in the elderly). When administered orally or intravenously, the in vivo situation of this product is roughly the same, and its elimination half-life is approximately 3 hours. It may be extended to 5 hours for the elderly. The drug is completely metabolized and the metabolites are excreted by the kidneys (75%) and liver (25%). Plasma protein binding rate is 75%.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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