What are the dangers of taking baricitinib?

Baricitinib (Baricitinib) is an oral drug that is a type of Janus kinase inhibitor (JAK inhibitor). It is used to treat rheumatoid arthritis and other autoimmune diseases such as rheumatoid arthritis in adults. Although baricitinib has shown some effectiveness in treating these diseases, it may also be associated with some hazards and side effects. The dangers of baricitinib are described in detail below.

1.Immunosuppressive effects: Baricitinib reduces the activity of the immune system by inhibiting theJanuskinase signaling pathway. This immunosuppressive effect may increase the patient's risk of infection. When the function of the immune system is suppressed, patients may be susceptible to infections by microorganisms such as bacteria, viruses, and fungi. Therefore, patients should remain vigilant about maintaining good personal hygiene and avoiding contact with known sources of infection while taking baricitinib.

2.Skin problems: Patients taking baricitinib may develop skin-related problems. Common side effects include rash, itching, dry skin, hair loss, and eczema. Some patients may also experience severe skin reactions such as hives, photosensitivity, and skin ulcers. If patients develop skin problems, they should inform their doctor promptly so they can be evaluated and treated.

3.Digestive system problems: Baricitinib may have adverse effects on the digestive system. Some patients may experience digestive system symptoms such as nausea, vomiting, abdominal pain, diarrhea, and gastrointestinal bleeding. While using baricitinib, patients should pay attention to their diet, avoid irritating foods and drinks, maintain appropriate fluid intake, and follow their doctor's recommendations.

4.Blood problems: Patients taking baricitinib may develop blood-related problems. This includes anemia (lower hemoglobin levels), lowered white blood cell count, and lowered platelet count. These problems may increase a patient's risk of infection, bleeding, and bruising. Doctors will regularly monitor patients' blood levels to ensure safe use of baricitinib.

5.Increased blood lipids and blood sugar levels: Patients taking baricitinib may experience increased blood lipids and blood sugar levels. This can lead to high cholesterol and high blood sugar, increasing the risk of cardiovascular disease and diabetes. While taking baricitinib, patients should check their lipid and blood sugar levels regularly and follow their doctor's recommendations for managing these problems.

6.Cardiovascular risk: Baricitinib use is associated with an increased risk of cardiovascular events, such as heart disease and stroke. Patients should pay close attention to cardiovascular symptoms such as chest pain, dyspnea, and palpitations while taking baricitinib. If these symptoms occur, seek medical attention immediately.

7.Risk of depression and suicide: Depression, anxiety, and suicidal tendencies may occur in patients taking baricitinib. If patients develop these psychological symptoms while using drugs, they should inform their doctor immediately and seek timely help and support.

Overall, baricitinib has shown some effectiveness in treating rheumatoid arthritis and other autoimmune diseases, but its use may also be associated with some hazards and side effects. Patients should pay close attention to any adverse reactions while using baricitinib and inform their doctors promptly. Only proper use and monitoring under the guidance of a doctor can minimize potential harm.

Baricitinib has been launched in China and is included in medical insurance. Patients can purchase it domestically. Due to different medical insurance reimbursement policies in different regions, the reimbursement ratio is also different. The price is about 1200~1600 yuan. For specific prices, please consult the local pharmacy or the medical insurance bureau. Baricitinib has both original and generic drugs abroad. The original drug is mainly Eli Lilly’s original drug, and its price is higher than in China. Generic drugs are mainly Bangladeshi generic drugs, and the price is around 450 yuan. The ingredients of original drugs and generic drugs are basically the same.