培米替尼是什么药？

What is pemetinib? Belongs to a class of drugs called kinase inhibitors. It works by blocking the action of abnormal proteins that signal cancer cells to multiply. This helps stop or slow the spread of cancer cells and is suitable for:

Cholangiocarcinoma that has metastasized (spread to other parts of the body) or is locally advanced and cannot be cured by surgery, as well as for the treatment of cholangiocarcinoma patients with FGFR2 gene fusions or other changes in the FGFR2 gene structure.

Cholangiocarcinoma is a rare cancer that develops in the long, thin bile ducts that carry digestive juices from the liver to the gallbladder and small intestine. At the time of diagnosis, most patients with cholangiocarcinoma have an advanced stage, meaning they cannot undergo surgical treatment. For these patients, chemotherapy combinations have become the standard initial treatment. Fibrocyte growth factor receptor 2 (FGFR2) fusions are found in the tumors of approximately 9% to 14% of patients with cholangiocarcinoma. Pemetinib prevents tumor growth and spread by inhibiting FGFR2 in tumor cells.

Pemetinib dosage: Orally. Usually taken once daily with or without food during the first 14 days of a 21-day cycle.

Precautions for pemetinib:

1. Use with caution if you are allergic to pemetinib. Many other drugs may also interact with pemetinib, and your doctor should be informed of the drugs you are using, especially St. John's wort. Do not eat large amounts of grapefruit or drink grapefruit juice while taking this medicine.

2. Women who are preparing to become pregnant or are already pregnant are not recommended to use it and must use strict contraception during use. Pemetinib may harm the fetus. Breastfeeding women should not breastfeed while taking pemetinib and for 1 week after the last dose.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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