恶性胶质瘤新药卡莫司汀晶片植入物效果如何呢？

Glioblastoma multiforme (GBM) is the most common brain tumor. U.S. statistics show that the 5-year survival rate of GBM is only 13%. Its traditional treatment includes tumor resection and radiotherapy and chemotherapy, but the median survival period is only 12 to 15 months. It is reported that traditional treatment combined with (Carmustine) implantation to remove the cavity can increase survival time.

So, how effective is the new malignant glioma drug carmustine chip implant?

To evaluate the therapeutic effect of conventional treatment combined with carmustine chip implants versus no implant (control group) in patients with newly diagnosed glioblastoma multiforme.

Four randomized controlled trials (RCTs) and 5 cohort studies were included, with a total of 1186 patients. Meta-analysis of RCTs: the median survival time and incidence of increased intracranial pressure in the carmustine chip implant group were significantly higher than those in the control group, and the difference was statistically significant (P<0.05); while there was no statistically significant difference in the incidence of cerebrospinal fluid leakage and convulsions (P>0.05). Mela analysis of the cohort study: the median survival time and 1-year postoperative survival rate of the carmustine chip implant group were significantly higher than those of the control group, and the difference was statistically significant (P<0.05).

It is concluded that traditional treatment combined with carmustine chip implants can significantly increase the median survival time and 1-year postoperative survival rate of patients with newly diagnosed glioblastoma multiforme, without increasing the incidence of other adverse reactions except for increased intracranial pressure.

Weakness, nausea, depression, constipation, abnormal wound healing, cerebral edema, vomiting, etc. have been found in studies.

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