恶性胶质瘤新药卡莫司汀晶片植入物效果怎么样？需要注意什么？

Carmustine, also called carmustine, is a commonly used intravenously administered chemotherapy drug for the treatment of malignant glioma. At the implantation site, carmustine will slowly dissolve and release high-concentration carmustine directly to the tumor site, minimizing the spread of the drug to other sites. Carmustine chip implant is an alkylating drug first developed by Emcure Pharmaceuticals Ltd.

So, how effective is the new malignant glioma drug carmustine chip implant?

One trial included a total of 787 patients, 354 in the implant group and 433 in the standard group. The trial demonstrates that carmustine wafer implants combined with maximal safe resection + standard chemoradiotherapy may represent a promising first-line treatment option in adult patients with supratentorial GBM. In the whole group analysis, the HR of PFS in the implanted group vs. the standard group was 0.81. The median PFS benefit was 2 months, 12.0 months in the implant group vs. 10 months in the standard group. Carmustine chip implants were associated with longer PFS in the total and subtotal resection groups but not in the partial resection group.

So, what should you pay attention to when treating carmustine chip implants? Carmustine chip implants can cause fetal harm; monitor patients for signs of obstructive hydrocephalus during treatment; monitor patients for complications from craniotomy; monitor patients for symptoms of bacterial or chemical meningitis; monitor patients for signs of increased intracranial pressure; monitor patients for seizures following implantation. Patients with different physiques will have different side effects after taking the medication. Pay attention to your own reactions during treatment. If you are intolerant, contact your doctor in time to change the treatment plan, but you cannot change the medication plan on your own. For more details about carmustine chip implants, please refer to the package insert.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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