阿那莫林的用法用量

Anamulin was developed by Ono of Japan and was approved by the US FDA on April 28, 2021. It is mainly targeted at the symptoms of weight loss and loss of appetite in patients with non-small cell lung cancer, gastric cancer and other malignant tumors. Proper use of this medication is critical to improving the patient's nutritional status. This article will introduce the relevant information of Anamorelin in detail from three aspects: usage and dosage, side effects, and medication for special groups.

Usage and Dosage of Anamorelin

The medication regimen needs to be strictly followed by the doctor’s instructions. The correct usage and dosage directly affects the therapeutic effect.

Standard dosage and administration

The recommended dosage for adults is 100 mg once a day, which should be taken on an empty stomach. You should avoid eating within 1 hour after taking the medicine to avoid affecting the absorption of the medicine. Tablets should be swallowed whole and not chewed or crushed.

Treatment course and efficacy evaluation

If there is no sign of weight gain or appetite improvement after 3 weeks of treatment, discontinuation of the drug should be considered. The maximum medication period does not exceed 12 weeks. If it is used beyond the period, a doctor must evaluate the necessity of continued medication. Weight changes and nutritional status need to be monitored regularly during treatment.

Principles for dose adjustment

When serious adverse reactions occur, it may be necessary to suspend medication or adjust the dose. Abnormal electrocardiogram, liver function damage, or significant increase in blood sugar require prompt medical treatment, and the doctor will decide whether to continue treatment.

Standard use of anamorelin can maximize its cachexia-improving effect while reducing the risk of adverse reactions.

Side effects of anamorelin

Understanding the potential side effects of anamorelin can help patients detect abnormalities in time and take countermeasures.

Common adverse reactions

Suppression of the conduction system manifests itself as prolonged PR interval or QRS wave on electrocardiogram, with a high incidence rate. Elevated blood sugar and liver function abnormalities are also common and require regular monitoring. Others include digestive system symptoms such as difficulty breathing, nausea, and diarrhea.

Serious adverse reactions

QT interval prolongation may induce serious arrhythmia. Severe liver damage may manifest as jaundice. Hyperglycemia may induce acute complications such as diabetic ketoacidosis.

Side Effect Management

It is necessary to comprehensively assess the patient’s basic condition before taking medication. Check electrocardiogram, liver function and blood sugar regularly during treatment. If abnormalities occur, the dose should be reduced or discontinued promptly, and symptomatic treatment measures should be taken if necessary.

Close monitoring of side effects can help early detection and management of drug-related adverse reactions.

Medication of Anamorelin for Special Populations

When using Anamorelin for different groups of people, individual differences need to be taken into consideration and personalized medication plans should be formulated.

Pregnant and lactating women

Consider use only when the benefits clearly outweigh the risks. The drug may affect the fetus through the placenta or milk, and lactating women should suspend breastfeeding while taking the drug.

Pediatric patients

There is a lack of medication data for children and must be used under the strict supervision of professional physicians. Special attention should be paid to growth and development monitoring and adverse reaction observation.

Elderly patients

The elderly have reduced physiological functions and drug metabolism may slow down. It is recommended to reduce the initial dose and strengthen electrocardiogram and liver and kidney function monitoring.

Special groups need to be more cautious when using medication, and adjust dosage and strengthen monitoring when necessary.