【你所关心】阿那莫林的使用方法及副作用

Cancer cachexia is a clinical syndrome characterized by abnormal metabolism of carbohydrates, fats and proteins, which mainly manifests as weight loss, loss of appetite, anemia, weakness, etc. Cancer cachexia has a high incidence rate and is more common in patients with advanced cancer. Its exact pathogenesis is not yet fully understood. It is currently believed that immune status, inflammatory factors and oxidative stress play an important role in the occurrence and development of cachexia. In January 2021, it received marketing approval in Japan (trade name Adlumiz) for the treatment of cachexia in patients with non-small cell lung cancer, gastric cancer, pancreatic cancer or colorectal cancer. Anamorelin is an orally active small molecule CHS with an extended half-life of 7 hours, developed by Helsinn Therapeutics. Anamorelin increased plasma GH, IGF-1 and IGFBP-3 levels and body weight in a dose-dependent manner without significant changes in the levels of other anterior pituitary hormones or glucose.

: The usual dose for adults is 100 mg taken orally once a day on an empty stomach.

: Tachycardia, bradycardia, suppression of stimulation conduction system, abnormal electrocardiogram, increase in serum γ-glutamyl transpeptidase, increase in glycated hemoglobin, upper ventricular extrasystoles, increase in blood bilirubin, atrioventricular block, decrease in blood pressure, palpitations, hyperglycemia, exacerbation of diabetes, liver dysfunction, etc.

Finally, the editor of Medical Companion Travel hopes that patients who are currently using Anamorelin will not believe or spread rumors. There is currently a lot of unreliable information on the Internet that conveys wrong information to everyone. For example, increasing the dose of the drug can double the therapeutic effect, or reducing the dose of the drug can avoid the occurrence of side effects. These are without any basis. Only by following the doctor's instructions can the effect of the drug itself be maximized.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.