阿那莫林效果好吗,作用机制是怎样的?

Cancer cachexia may occur at all stages of tumors and is a complex metabolic disorder syndrome characterized by weight loss (especially loss of muscle mass) and cancer-related anorexia, which seriously affects the patient's quality of life and shortens survival. It is a novel, oral, selective ghrelin receptor agonist that can be used to treat cancer cachexia. So, is Anamorelin effective and what is its mechanism of action?

Is Anamorelin effective?

The ONO-7643-04 study on non-small cell lung cancer (NSCLC) and the ONO-7643-05 study on colorectal cancer, gastric cancer, and pancreatic cancer have confirmed the efficacy of anamorelin. The results of these trials have shown that anamorelin can increase body weight, increase muscle mass, and increase appetite in cachexia in cancer patients, significantly improving anorexia and weight loss, with durable efficacy and good safety and tolerability. Anamorelin improves weight loss and loss of appetite in patients with cancer cachexia by simulating the effects of ghrelin secreted from the gastrointestinal tract.

Anamorelin's mechanism of action

Anamorelin has significant agonistic and binding activity on growth hormone receptors and stimulates growth hormone release in vitro. Through its activity, anamorelin has orexigenic and pro-anabolic effects, and by inhibiting NF-κB, anamorelin is able to reduce the growth of pro-inflammatory cytokines and prevent myolysis (inhibition of proteolysis).

Anamorelin was developed by Ono Pharmaceutical. Cancer cachexia (cancer cachexia) in patients with non-small cell lung cancer, gastric cancer, pancreatic cancer, colorectal cancer and other malignant tumors can be treated with anamorelin. It is easy to take and has significant efficacy. It has attracted the attention of patients as soon as it was launched. The launch of Anamorelin will provide a new treatment option for patients with cancer cachexia who previously had no targeted drugs and help improve the quality of life of such patients. The above is the content of whether Anamorelin is effective and its mechanism of action.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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