他泽司他是什么药？治疗什么病？

What kind of medicine is tazetostat? What disease is treated? Epithelioid sarcoma is a relatively rare type of soft tissue sarcoma, accounting for less than 1% of all soft tissue sarcomas. Epithelioid sarcomas mostly originate in the subcutaneous soft tissues of the limbs. Before cancer cells metastasize, surgical resection is the main treatment method. Chemotherapy and radiotherapy can also be used. However, epithelioid sarcoma is very prone to metastasis. Even after active treatment, epithelioid sarcoma is still likely to metastasize locally or between regions. About 50% of patients have already metastasized when they are diagnosed. Patients with metastatic epithelioid sarcoma often die. Before tazemetostat was approved by the FDA, there were no specific treatments for epithelioid sarcoma. The mechanism of action of tazetostat is to block the activity of methyltransferase EZH2, thereby inhibiting the growth of cancer cells.

Tazetostat is a first-in-class EZH2 (Zeste gene enhancer homolog 2) inhibitor. EZH1/2 is a histone methyltransferase. Mutated or overexpressed EZH1/2 inhibits the transcriptional activity of tumor suppressor genes. By inhibiting EZH2, tazetostat can inhibit the methylation of histone H3 lysine 27 (H3K27) and restore the expression of tumor suppressor genes.

For upper respiratory tract infection, fatigue, vomiting, constipation, musculoskeletal pain, pain, nausea, loss of appetite, abdominal pain, etc. During the medication period, patients must not increase or decrease the dose of the drug by themselves. Tazerestat will not improve the therapeutic effect just because the dose of the drug is increased, so do not use the medication blindly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.