服用氢化可的松片的副作用

(Hydocortisone) is an important adrenocortical hormone. It is not only one of the most important immediate anti-inflammatory drugs and immunosuppressants, but also has the characteristics of low dose, long duration and accurate efficacy. It is often used in clinical practice as a replacement therapy for the treatment of adrenal insufficiency and congenital adrenal hyperplasia, and has shown good efficacy. However, despite this, patients may still experience some side effects when taking hydrocortisone tablets. Patients need to pay high attention to this.

Common adverse reactions include the following categories:

1. Long-term use of hydrocortisone tablets can cause the following side effects: iatrogenic Cushing's syndrome, face and posture, weight gain, lower limb edema, purple lines, easy bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, osteoporosis and fractures (including spinal compression) fractures, pathological fractures of long bones), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, growth inhibition in children, glaucoma, cataracts, benign increased intracranial pressure syndrome, impaired glucose tolerance and exacerbation of diabetes.

2. Patients who use hydrocortisone tablets may experience psychiatric symptoms: euphoria, excitement, delirium, restlessness, disorientation, and may also manifest as depression. Psychiatric symptoms are particularly likely to occur in people suffering from chronic wasting diseases and those who have had mental disorders in the past.

3. Concurrent infection is the main adverse reaction of adrenocortical hormone. Mainly fungi, Mycobacterium tuberculosis, Staphylococcus aureus, Proteus, Pseudomonas aeruginosa and various herpes viruses.

4. Glucocorticoid withdrawal syndrome: Sometimes patients experience dizziness, fainting tendencies, abdominal or back pain, low fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, and weakness after discontinuation of use. If after careful examination, adrenal insufficiency and relapse of the original disease can be ruled out, it can be considered a dependence syndrome on glucocorticoids.

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