氢化可的松片的治疗效果怎么样？

In clinical practice, it is mainly used for the replacement treatment of adrenal insufficiency and the treatment of congenital adrenal hyperplasia. At the same time, the drug can also be used for rheumatoid arthritis, rheumatic fever, gout, bronchial asthma, allergic diseases, and it can also be used for severe infection and anti-shock treatment.

One of the double-blind, randomized, placebo-controlled, multi-center research projects across Europe is worthy of attention. A total of 500 patients with septic shock were enrolled in the study. Patients in the experimental group were treated with hydrocortisone, 50 mg intravenously q6h for 5 days, then 50 mg q12h for 3 days, and then 50 mg qd for 3 days. The conclusion is that septic shock that is poorly treated by fluid resuscitation and vasoactive drugs, regardless of whether it responds to ACTH stimulation, can be treated with low-dose hydrocortisone. Although the improvement in mortality is unclear, it can correct shock faster. There is also evidence that the use of hydrocortisone in patients with septic shock can reduce the occurrence of post-traumatic stress disorder and improve the mental state of patients recovering from shock.

It is prohibited for those allergic to other steroid hormones. Patients with the following diseases are generally not suitable for use. In special cases, the pros and cons should be weighed, but attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis surgery, fractures, trauma repair period, corneal ulcers, hyperadrenocorticism, hypertension, diabetes, pregnant women, fungal infections that cannot be controlled by antibiotics, chickenpox, measles, severe osteoporosis, etc.