降压药依普利酮的作用是什么

What do antihypertensive drugs do? In 2002, eplerenone was first approved for marketing in the United States, with the English name: Inspra. Its indications are the treatment of hypertension, heart failure and myocardial infarction. It has significant effects, few adverse reactions, and good tolerance. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. Eplerenone, as a new generation of selective aldosterone receptor antagonist, provides a new method for the treatment of cardiovascular diseases.

In a study, elderly patients with systolic hypertension were treated with eplerenone (50-200) mg daily and amlodipine (2.5-10) mg daily. The results showed that both drugs had the same effect in lowering systolic blood pressure, while amlodipine lowered diastolic blood pressure more significantly.

After 24 weeks of treatment, the researchers found that both drugs improved carotid-femoral and carotid-radial artery pulse rates in terms of target organ protection. In terms of the incidence of adverse reactions, 19.9% ​​of the amlodipine group developed peripheral edema, while only 2.7% of the eplerenone group developed hyperkalemia. 0.4% of the amlodipine group developed hyperkalemia, and 0.9% of the eplerenone group developed hyperkalemia. In summary, eplerenone is effective in treating patients with hypertension and has a relatively high safety profile.

Studies have shown that for severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of eplerenone can significantly reduce blood pressure, especially the decrease in systolic blood pressure is more significant. Combined treatment with angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers can improve patients' quality of life and reduce mortality in severe heart failure and myocardial infarction.

In summary, it can significantly lower blood pressure and bring new and effective solutions to the treatment of patients with hypertension.

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