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(eplerenone) was developed by Pfizer of the United States and was first launched in the United States in 2004. It is suitable for essential hypertension and heart failure after myocardial infarction. For severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of eplerenone can significantly reduce blood pressure, especially the decrease in systolic blood pressure is more significant. Combined treatment with angiotensin-converting enzyme inhibitors (ACEI) and receptor blockers can improve patients' quality of life and reduce mortality in severe heart failure and myocardial infarction. Is the antihypertensive drug eplerenone available in pharmacies? Currently, eplerenone has not been approved for marketing in China, so patients cannot purchase the drug in domestic pharmacies.

Eplerenone is administered orally and can be used alone or in combination with other drugs related to the treatment of hypertension. The recommended dose for adults is an initial dose of 50 mg, once a day. The maintenance dose is 50mg, 1-2 times a day. Maximum dose: 100 mg/day. If the patient does not respond adequately to the initial dose during treatment, it can be increased to 50 mg twice daily.

Untreated hypertension and heart failure are both associated with adverse pregnancy outcomes. The use of mineralocorticoid receptor antagonists is not recommended for the treatment of chronic isolated hypertension in pregnant women and should generally be avoided in women of reproductive potential.

In recent years, more and more evidence has shown that other tissues, especially the brain, heart and blood vessels, can also independently synthesize aldosterone. Not only that, it can also directly affect blood pressure, damage the heart, brain, kidneys and other organs, seriously affecting the patient's health. Eplerenone is a selective aldosterone receptor antagonist that only acts on mineralocorticoid receptors and does not act on androgen and progesterone receptors. It has fewer side effects.

(eplerenone) also has a good antihypertensive effect on simple systolic hypertension, and has a good antihypertensive effect on diet-induced obesity-related hypertension. In addition, eplerenone can significantly reduce the ultrafiltration effect of glomeruli and reduce albuminuria in patients with hypertension. This renal protective effect is more obvious for hypertensive patients with diabetes.

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