环丝氨酸（Coxerin）中文说明书

[drug name]

[Properties] Cycloserine powder is white to yellow-white crystals or crystals. The product is slightly soluble in water and slightly soluble in ethanol (95).

[Indications/Function Indications] It is used to treat active tuberculosis that is sensitive to this product, but it needs to be used in combination with other effective anti-tuberculosis drugs. Since it may cause severe mental disorder, its clinical application is limited.

[Specification model] 0.25g*10s

[Usage and Dosage] Oral administration: 1. Adults take 0.5-1g per day, divided into 2 times, 0.25g each time for the first 2 weeks, 2 times a day, the maximum dose is 1g per day. 2. For children, take 5 to 20 mg/kg per day, divided into 2 to 4 times, with half the dose for the first dose.

[Adverse Reactions] Adverse reactions are mainly central nervous system reactions. 1. Commonly seen are headache, dizziness, drowsiness, abnormal behavior, mental depression, orientation or memory impairment, tremor, convulsions, restlessness, convulsions or coma. 2. Occasionally, heart failure, fever, nausea, vomiting, abdominal pain, abnormal liver function, and elevated AST or ALT may be aggravated. This product can induce psychotic reactions, mental disorders, and suicidal tendencies.

[Taboos] 1. It is forbidden for people suffering from epilepsy, severe depression, irritability or mental illness. 2. It is contraindicated in patients with severe liver and kidney damage. 3. It is forbidden for those who like to drink.

【Precautions】 1. Use with caution: Use with caution in patients with cardiac insufficiency. The safety for children has not yet been determined. Pregnant and breastfeeding women should use with caution. 2. The adverse reactions of this product are related to the blood concentration and dosage. Especially when the dosage exceeds 500 mg per day, it is best to monitor the blood concentration during treatment and control it below 30 μg/ml. The blood sample for measurement should be taken before the first dose of each day. Patients with renal insufficiency should be monitored once a week. 3. Nervous reactions include both neurological and mental aspects. Muscle twitches and convulsions may occur. Once they occur, the drug should be stopped immediately and a large dose of vitamin B6 should be given at the same time for prevention.

The above instructions are instructions. Please use the medicine under the guidance of a doctor.