依普利酮（Planep）上市没？

Eplerenone (alias: eplerenone, Inspra) is a new type of selective aldosterone receptor antagonist. It has stronger aldosterone antagonism than spironolactone and has extremely low affinity for androgen and progesterone receptors. It has few adverse reactions. It has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction. It has good tolerance and is a good alternative drug to spironolactone.

For severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of eplerenone can significantly reduce blood pressure, especially the decrease in systolic blood pressure is more significant. Combined treatment with angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers can improve patients' quality of life and reduce mortality in severe heart failure and myocardial infarction. Is eplerenone (Planep) on the market?

Eplerenone is already on the market. In 2002, eplerenone was first launched in the United States. It is mainly used clinically to treat hypertension. In 2003, the FDA approved eplerenone for the treatment of heart failure after acute myocardial infarction.

Eplerenone can be used clinically to treat heart failure and hypertension. If it is to treat heart failure, it is relatively suitable for patients with left ventricular hypertrophy and left ventricular ejection fraction less than or equal to 40%. It can improve the quality of life and prognosis of such patients.

If it is to treat high blood pressure, eplerenone (also known as: eplerenone, Inspra) can be used alone or in combination with other antihypertensive drugs to treat high blood pressure.

For patients with heart failure after myocardial infarction, generally speaking, the initial dosage is 25 mg, once a day, and the dosage can be gradually increased. For example, within four weeks, it can be increased to 50 mg, once a day orally according to the patient's actual condition.

If it is used to treat hypertension, it is recommended that the initial dose of eplerenone is 50 mg, taken orally once a day. Depending on the improvement of the patient's blood pressure, if the improvement is not obvious, it can be increased to 50 mg, taken orally twice a day.