依普利酮（Planep）说明书

Eplerenone (Planep) instructions

[Drug name] Eplerenone, Planep, Inspra

[Indications of eplerenone]

1. Congestive heart failure after acute myocardial infarction: Eplerenone can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that this product can also be used for heart failure after acute myocardial infarction and congestive heart failure after acute myocardial infarction;

2. Anti-hypertensive: Eplerenone can be used alone or in combination with other anti-hypertensive drugs for the treatment of hypertension.

[Eplerenone Usage and Dosage] All patients must have their serum potassium measured before treatment with eplerenone, within the first week and one month after starting treatment or adjusting the dose, and serum potassium should be evaluated regularly thereafter.

Dosage after acute myocardial infarction: The starting dose is 25 mg per day. Under conditions acceptable to the patient within 4 weeks, the titrated dose will be adjusted to 50 mg per day. The dose should also be adjusted according to the patient's potassium level.

Hypertension: 50 mg once a day, either alone or in combination with other antihypertensive drugs. For patients with poor response, adjust to 50 mg twice a day. Higher doses are not recommended.

[Adverse reactions of eplerenone]

The main adverse reactions include: cough, diarrhea, abdominal pain, angina, myocardial infarction, proteinuria, headache, dizziness, fatigue, flu-like symptoms, etc.

Other adverse reactions include: gynecomastia, abnormal vaginal bleeding; increased levels of serum potassium, triglycerides, cholesterol, alanine aminotransferase, γ-glutamyl transferase, creatinine, and uric acid, and decreased serum sodium levels.

[Advantages of eplerenone treatment]

(1) For the treatment of heart failure after acute myocardial infarction, combined with standard treatment drugs can reduce the total mortality in the treatment group by 15% (P=0.008);

(2) Eplerenone and enalapril are equally effective in reversing left ventricular hypertrophy and hypertension, with fewer cough side effects, and the combined effect is more obvious;

(3) There are few adverse reactions. Except for the adverse reactions of increased blood potassium, other adverse reactions are no different from the placebo group;

(4) Eplerenone has almost no sex hormone-related side effects of spironolactone.