依普利酮在中国上市了吗？

It was first launched in the United States in 2002 and is mainly used clinically to treat hypertension. In 2003, the FDA approved eplerenone for the treatment of heart failure after acute myocardial infarction. So, has eplerenone been launched in China?

It is understood that eplerenone was approved for clinical use by the State Food and Drug Administration in 2002, but it has not been officially launched in China!

According to Medical Travel, we learned that India’s Lupine Pharmaceuticals sells eplerenone 50 mg × 100 tablets for about $500. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. Clinically, it may be accompanied by functional or organic damage to the heart, brain, kidney and other organs. About 60% of patients with hypertension have a family history. It is currently believed to be caused by polygenic inheritance, and 30% to 50% of patients with hypertension have a genetic background.

Eplerenone is a new generation selective aldosterone antagonist that can be used alone or in combination with other antihypertensive drugs for the treatment of hypertension. It also has a good antihypertensive effect on simple systolic hypertension and has a good antihypertensive effect on diet-induced obesity-related hypertension. In addition, eplerenone can significantly reduce the ultrafiltration effect of glomeruli and reduce albuminuria in patients with hypertension. This renal protective effect is more obvious for hypertensive patients with diabetes.

Usage and dosage of eplerenone: Common dosage for adults with congestive heart failure: Initial dosage: 25 mg orally, once a day; and gradually increase to the target dose within 4 weeks as tolerated by the patient. Target dose: 50 mg orally once daily.

Common dosages for adults with hypertension: It can be used alone or in combination with other antihypertensive drugs. Initial dose: 50 mg orally once daily; Maintenance dose: 50 mg orally once or twice daily; Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.