依普利酮在国内的售价是多少呢？

It is a new type of selective aldosterone receptor antagonist that has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction. It has fewer adverse reactions and is well tolerated. It is a good alternative to spironolactone.

For severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of eplerenone can significantly reduce blood pressure, especially the decrease in systolic blood pressure is more significant. Combined treatment with angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers can improve patients' quality of life and reduce mortality in severe heart failure and myocardial infarction.

It was approved for clinical use by the State Food and Drug Administration in 2002. So, what is the selling price of eplerenone in China?

The price of eplerenone in China: It is understood that although eplerenone is used clinically in China, it has not yet been officially launched in the country. Therefore, we cannot provide you with a specific price!

According to Medical Travel, a box of 50 mg × 100 tablets of eplerenone from India's Lupine Pharmaceuticals sells for about $500. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

Effects of eplerenone on hypertension:

1. Eplerenone shows a sustained antihypertensive effect on systolic blood pressure in unilateral nephrectomized hypertensive rats with continuous aldosterone administration/salt loading.

2. Eplerenone showed sustained antihypertensive effects on systolic blood pressure during 2 weeks of administration in stroke-prone spontaneously hypertensive rats (SHRSP). The antihypertensive effect of ACE inhibitors is significantly enhanced when combined with lisinopril.

3. In Dahl salt-sensitive rats, the salt-sensitive low-renin hypertension animal model, eplerenone showed a dose-dependent antihypertensive effect on systolic blood pressure after continuous administration for 4 weeks.

Contraindications of eplerenone:

1. It is forbidden for patients with hyperkalemia;

2. It is forbidden for patients with liver and kidney dysfunction;

3. It is forbidden for those who are allergic to eplerenone;

4. Use with caution if you are pregnant or breastfeeding;

5. Use with caution if you are using other drugs (which may strengthen or weaken the efficacy of the drug, so please use other general-purpose drugs and food with caution).