Planep国内上市了没？

It selectively acts on aldosterone receptors, is highly selective for mineralocorticoid receptors, and has less effect on androgen and progesterone receptors. Its affinity for mineralocorticoids is 15 to 20 times that of spironolactone, while its affinity for androgen and progesterone receptors is 500 times smaller than that of spironolactone. times, so sex hormone-related adverse reactions are less likely to occur; aldosterone has a variety of pathophysiological effects, which can cause central hypertension, accelerate endothelial damage (catecholamines enhance its effects), reduce heart rate variability, induce ventricular arrhythmia, promote sodium retention, potassium and magnesium loss, promote myocardial fibrosis, necrosis and inflammation, and damage the fibrinolytic system. In a study of systolic hypertension in the elderly, 269 patients were treated with Planep (50-200) mg daily and amlodipine (2.5-10) mg daily. The results showed that both drugs had the same effect in lowering systolic blood pressure, while amlodipine lowered diastolic blood pressure more significantly. In terms of target organ protection, both drugs improved carotid-femoral and carotid-radial pulse rates after 24 weeks of treatment. In terms of the incidence of adverse reactions, 19.9% ​​of the amlodipine group developed peripheral edema, while only 2.7% of the Planep group developed hyperkalemia. 0.4% of the amlodipine group developed hyperkalemia, compared with 0.9% of the Planep group.

Has Planep been launched in China?

Planep was developed by Pfizer of the United States and first launched in the United States in 2002. It is mainly used clinically to treat hypertension. In 2003, it was approved by the FDA for the treatment of heart failure after acute myocardial infarction. Planep was approved for clinical use by the State Food and Drug Administration in 2002, but it has not been marketed in my country, so Chinese patients cannot currently buy Planep in domestic pharmacies.

  Side effects include: cough, diarrhea, abdominal pain, angina, myocardial infarction, proteinuria, headache, dizziness, fatigue, flu-like symptoms, etc. Other adverse reactions of Planep include: gynecomastia, abnormal vaginal bleeding; increases (serum potassium, triglycerides, cholesterol, alanine aminotransferase, γ-glutamyl transferase, creatinine, uric acid levels), and decreased serum sodium levels.