Planep的价格是多少？

Binds to mineralocorticoid receptors, thereby blocking the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone synthesis occurs primarily in the adrenal gland and is regulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in epithelial tissues (such as the kidneys) and non-epithelial tissues (such as the heart, blood vessels, and brain) and increases blood pressure by inducing sodium reabsorption and possibly other mechanisms.

How much does Planep cost? 

Planep, which is marketed in the United States, is produced by Pfizer Ltd./Pfizer Pharmaceuticals of the United States. It has two specifications, with different prices according to different rules: Pharmaceutical specification 1: 25mg-30 tablets/box, price: $118.71/USD; Pharmaceutical specification 2: 50mg-30 tablets/box, price: $124.09 /USD; Planep, which is marketed in India, is produced by Lupine Pharmaceuticals of India. Pharmaceutical specification 1: 25mg-15 tablets/box, price: MRP286.5/unit: Indian rupees; pharmaceutical specification 2: 50mg-10 tablets/box/box, price: MRP356.6/unit: Indian rupees. Specification 3: 50mg-100 tablets/box is equivalent to about RMB 500$.

Planep side effects

1. Endocrine and metabolism: hyperkalemia (heart failure, post-myocardial infarction: >5.5meq/L: 16%; ≥6meq/L: 6%], hypertension, >5.5meq/L: 400mg: 9%; dose ≤200mg: ≤1%), hypertriglyceridemia (1%-15%; dose-related). 

2. 1%-10% of side effects: central nervous system: dizziness, fatigue; endocrinology and metabolism: hyponatremia (2%; dose-related), proteinuria, gynecomastia, hypercholesterolemia; gastrointestinal tract: diarrhea, abdominal pain; genitourinary system: abnormal vaginal bleeding, breast pain (males: ≤1%); kidney: elevated serum creatinine (heart failure, post-myocardial infarction: 6%); respiratory system: cough, flu-like symptoms. 

3. Symptoms of angioedema, increased blood urea nitrogen, increased liver enzymes, increased uric acid, and rash may occur in <1% of cases.