Planep一盒多少钱？

Binds to mineralocorticoid receptors, thereby blocking the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone synthesis occurs primarily in the adrenal gland and is regulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in epithelial tissues (such as kidneys) and non-epithelial tissues (such as heart, blood vessels and brain), and increases blood pressure by inducing sodium reabsorption and other possible mechanisms; Planep is a new type of selective aldosterone receptor antagonist, which was approved for clinical use by the State Food and Drug Administration in 2002. The pure product is white or off-white crystals. Its antagonism to aldosterone is stronger than that of spironolactone, and it has extremely low affinity for androgen and progesterone receptors. It has few adverse reactions and has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction. It has fewer adverse reactions and is well tolerated. It is a good alternative to spironolactone. The safety and effectiveness of Planep treatment have been verified in trials: the FDA (U.S. Food and Drug Administration) has approved Planep for use in patients with stable left ventricular systolic dysfunction (ejection fraction <40%) and congestive heart failure after acute myocardial infarction (MI) to improve survival rates. Planep is the first aldosterone receptor blocker approved for this indication. The FDA's approval was based on the results of the EPHESUS (Planep Efficacy and Survival Study in Heart Failure After Acute Myocardial Infarction) trial. In patients with heart failure after myocardial infarction, Planep plus standard care reduced mortality by 15% compared with placebo and standard care (ACE inhibitors and beta-blockers).

How much does a box of Planep cost?

Planep currently on the market includes the original drug of Pfizer Planep in the United States and the generic version of Planep from India's Lupine Pharmaceuticals. Different versions of Planep have different prices. Planep available in the United States is produced by Pfizer Ltd./Pfizer Pharmaceuticals of the United States. There are two specifications, and the prices are different according to different rules: Pharmaceutical specification 1: 25mg-30 tablets/box, price: $118.71 /USD; Pharmacy specification 2: 50mg-30 tablet bottle/box, price: $124.09/USD; produced in India by Lupine Pharmaceuticals, pharmaceutical specification 1: 25mg-15 tablet bottle/box, price: MRP286.5/unit: Indian rupee; Pharmacy specification 2: 50mg-10 tablet bottle/box, price: MRP356.6/unit: Indian rupee. Specification 3: 50mg-100 tablets/box is equivalent to about RMB 500$.