eplerenone用法用量

Approved in the United States in 2002, it has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction, has fewer adverse reactions and is well tolerated. Eplerenone has a protective effect on the liver, heart disease, and kidneys without damaging the organs. eplerenone can promote urination without losing potassium. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. Hypertension refers to an increase in systemic arterial blood pressure (systolic blood pressure and/or diastolic blood pressure) as the main feature (systolic blood pressure ≥ 140 mm Hg mm Hg, diastolic blood pressure ≥ 90 mm Hg mm Hg). Clinically, it may be accompanied by functional or organic damage to the heart, brain, kidney and other organs. About 60% of patients with hypertension have a family history. It is currently believed to be caused by polygenic inheritance, and 30% to 50% of patients with hypertension have a genetic background. Eplerenone is a new-generation selective aldosterone antagonist that can be used alone or in combination with other antihypertensive drugs for the treatment of hypertension. It also has a good antihypertensive effect on simple systolic hypertension and has a good antihypertensive effect on diet-induced obesity-related hypertension. In addition, eplerenone can significantly reduce the ultrafiltration effect of glomeruli and reduce albuminuria in patients with hypertension. This renal protective effect is more obvious for patients with hypertension combined with diabetes.

Eplerenone usage and dosage: Common dosage for adults with congestive heart failure: Initial dosage: 25 mg orally, once a day; and gradually increase to the target dose within 4 weeks as tolerated by the patient. Target dose: 50 mg orally once daily. Common dosages for adults with hypertension: It can be used alone or in combination with other antihypertensive drugs. Initial dose: 50 mg orally once daily; Maintenance dose: 50 mg orally once or twice daily; Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.