达那唑治疗遗传性血管性水肿的用法用量？

Hereditary angioedema (HAE) is a rare autosomal dominant genetic disease with an incidence rate of approximately 1:50 000 to 1:10 0001. It is mainly characterized by recurrent subcutaneous or submucosal edema. HAE can affect any part of the body, among which limbs, face, genitals, digestive tract, and respiratory tract mucosa are more common. At present, the most common drug to prevent HAE at home and abroad is the weak androgen danazol. The exact mechanism of androgen in HAE is unclear. It is currently believed that androgen may increase the synthesis of C1-INH in the liver. Some studies have shown that it can increase the concentration of serum C1-INH and complement factor 4 (C4). So, what is the dosage of danazol in the treatment of hereditary angioedema?

Danazol usage and dosage in the treatment of hereditary angioedema

Requirements for continued use of danoline in the treatment of hereditary angioedema should be individualized based on the patient's clinical response. It is recommended that patients start taking 200 mg two or three times daily. After a good initial response to prevent edematous attacks is achieved, appropriate continuing dosage should be determined by reducing the dose by 50% or less at intervals of 1 to 3 months or longer if pretreatment attack frequency dictates. If an attack occurs, increase the daily dose to 200 mg. During the dose adjustment phase, patient response needs to be closely monitored, especially if the patient has a history of airway compromise.

Danazol adverse reactions

The following have been reported with the use of danazol: Androgen-like effects including weight gain, acne, and seborrhea. Mild hirsutism, edema, alopecia, and voice changes manifesting as hoarseness, sore throat, or unstable or deepened pitch may occur and persist after treatment is discontinued.

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