英菲格拉替尼的用法用量

Infigratinib is a targeted therapy drug for patients with cholangiocarcinoma with abnormal FGFR2 genes. This article will introduce the relevant information of infigratinib in detail from three aspects: usage, dosage, price and medication for special groups, to help patients and doctors better understand the characteristics and usage of this drug.

Usage and Dosage of Infigratinib

The correct medication method is the key to exerting the efficacy of Infigratinib. Patients must strictly follow the doctor's instructions and ensure the medication is standardized.

Recommended dosage regimen

The standard dose of Infigratinib is 125 mg (100 mg + 25 mg capsule), once a day, taken continuously for 21 days and then stopped for 7 days, constituting a complete treatment cycle of 28 days. This intermittent dosing helps balance efficacy with side effects.

Specific requirements for taking medicine

The medicine needs to be taken on an empty stomach, 1 hour before a meal or 2 hours after a meal is the best time. Capsules should be swallowed whole and not chewed or crushed. If a dose is missed for more than 4 hours or vomiting occurs, there is no need to take a replacement dose, just continue with the next dose as originally planned.

Principles of dose adjustment

When adverse reactions occur, the dose can be gradually reduced: to 100mg for the first time, to 75mg for the second time, and to 50mg for the third time. Patients with liver function impairment need to adjust the dose according to the degree, with mild dosage being adjusted to 100 mg and moderate dosage being adjusted to 75 mg.

Standardized medication methods can maximize drug efficacy while reducing the occurrence of adverse reactions.

The price of Infigratinib

Understanding drug price information can help patients make a budget for treatment and choose the most suitable treatment plan.

Market price information

The current specification of generic drugs produced by Lucius in Laos is 100mg*21 capsules/box, and the price is approximately US$471. This price is more accessible than the original drug, providing patients with more choices.

Medical insurance coverage

Infigratinib has not yet been launched in China and has not been included in the scope of medical insurance reimbursement. If patients need to use it, they need to pay for it in full.

Recommendations on drug purchase channels

Patients can purchase generic drugs through formal channels, but they must pay attention to identify the authenticity of the drugs and choose reputable suppliers.

Reasonable price budgets and standardized drug purchase channels are important guarantees to ensure the continuity of treatment.

Infigratinib medication for special populations

There are differences in the medication regimens for different groups of people, and the medication strategy needs to be adjusted according to individual conditions.

Pregnant and lactating women

This drug is prohibited for pregnant women. Women of childbearing age must take effective contraceptive measures during treatment and for 1 month after stopping the drug. Breastfeeding women should stop breastfeeding.

Patients with abnormal liver and renal function

Patients with mild to moderate liver and renal impairment need to adjust the dose. The safety of the drug in patients with severe impairment has not yet been clarified and requires careful evaluation.

Elderly patients

The drug safety for elderly patients over 65 years old is equivalent to that of younger patients, and no special dosage adjustment is required.

Personalized medication plans for special groups can reduce drug side effects and improve treatment effects.