英菲格拉替尼的副作用是什么,多久一个疗程?

Infigratinib is a potent and selective ATP-competitive FGFR inhibitor for adult patients with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement. It was approved by the US FDA in 2021. So, what are the side effects and how long is the course of treatment?

What are the side effects of Infigratinib?

Infigratinib can improve patients' quality of life and prolong their survival, but it also has side effects. Common side effects include nail toxicity, stomatitis, alopecia, palmoplantar erythema syndrome, joint pain, dry eye syndrome, fatigue, dysgeusia, constipation, eyelash changes, loss of appetite, abdominal pain, dry mouth, blurred vision, diarrhea, dry skin, vomiting, etc. Patients are advised to follow the doctor's instructions and pay attention to their own reactions in time. If there is any intolerance, contact the doctor to adjust the medication.

How long is the course of Infigratinib treatment?

It is administered orally once a day, 125 mg each time, for 21 days, and then the treatment is stopped for 7 days, with a cycle of 28 days. Infigratinib can be continued until disease progression or unacceptable toxicity occurs. The specific course of medication must be determined by the doctor based on the patient's condition. Infigratinib should be taken at the same time every day and needs to be taken on an empty stomach, that is, at least 1 hour before and 2 hours after meals. Patients are advised not to change the dosage and usage at will.

Infigratinib blocks downstream signaling cascades by selectively binding and inhibiting FGFR activity, reducing cancer cell proliferation and inducing tumor cell death. The above is what the side effects of Infigratinib are and how long a course of treatment is. I hope it can help you!

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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