英菲格拉替尼用药剂量是多少？长期用会耐药吗

Infigratinib is a small molecule ATP-competitive tyrosine kinase inhibitor of FGFR indicated for the treatment of adult patients with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma and fibroblast growth factor receptor 2 (FGFR2) fusions or other rearrangements with FDA-approved testing. What's the dosage? Will long-term use lead to drug resistance?

Infigratinib dosage

The recommended dose of Infigratinib is 125 mg, taken orally once a day, with 21 consecutive days of medication and 7 days of discontinuation, with a 28-day treatment cycle. Patients should swallow the capsule whole with a glass of water and should not crush, chew, or dissolve. Infigratinib should be taken at the same time every day, at least 1 hour before meals or 2 hours after meals, on an empty stomach. The actual medication can be adjusted according to the patient's physical condition. Patients should follow the correct usage method when treating Infigratinib, and should not blindly increase or decrease the dosage of Infigratinib. Changing the dosage of medication without authorization may affect the condition or cause other adverse reactions, so medication should be used strictly in accordance with the doctor's diagnosis and treatment recommendations.

Infigratinib resistance

Resistance may develop with long-term treatment with Infigratinib. However, depending on each patient's physical condition, tolerance to the drug, and disease progression, the time for drug resistance to develop after treatment with Infigratinib, the specific manifestations of drug resistance, and treatment methods will also vary. This is all determined by the patient's own situation.

After patients develop resistance to Infigratinib, they cannot use other drugs without authorization, because incorrect medication may lead to other adverse reactions. Therefore, patients should go to the hospital promptly after developing drug resistance, where professional doctors will provide diagnosis and treatment and adjust the medication plan.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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