英菲格拉替尼怎么使用？有什么副作用？

Infigratinib is a small molecule ATP competitive tyrosine kinase inhibitor of FGFR. It was launched in the United States in May 2021 and is used to treat cholangiocarcinoma. It induces tumor cell death by reducing cancer cell proliferation. Today let’s take a closer look at how to use it? What are the side effects?

Before using Infigratinib, it is necessary to determine whether there is FGFR2 gene fusion or rearrangement. The recommended dose is 125 mg, taken orally once a day, for 21 days of continuous treatment, and 7 days of discontinuation. A treatment cycle of Infigratinib is 28 days. Patients need to note that the drug needs to be taken at a fixed time every day, on an empty stomach, 1 hour before meals or 2 hours after meals. Infigratinib should not be crushed, chewed, or dissolved. Swallow the entire capsule with a glass of water. The dosage should be adjusted according to the doctor's instructions. Patients should not increase or decrease the dosage of the drug at will to avoid intolerance reactions and affect the original condition.

Cholangiocarcinoma is a malignant tumor, and most patients are diagnosed at an advanced stage with a very poor prognosis. Infigratinib is the second targeted drug for cholangiocarcinoma. Although the treatment effect is remarkable, it also has side effects. So, what are the side effects of Infigratinib? Nail toxicity, dry skin, loss of appetite, stomatitis, dry eye syndrome, fatigue, alopecia, palmoplantar erythema sensory syndrome, joint pain, dysgeusia, constipation, eyelash changes, diarrhea, blurred vision and vomiting, abdominal pain, dry mouth, etc. are the main side effects of this drug. Patients should pay attention to their own reactions during medication. If they have intolerance, contact their doctor promptly and adopt a new treatment plan.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

Recommended related articles: