替莫唑胺在中国上市了吗?好购买吗？

Temozolomide is an important drug used to treat certain types of brain tumors. This article will discuss the marketing status, purchase convenience and efficacy of temozolomide in China, aiming to provide comprehensive information support for patients and their families.

Is temozolomide available on the market in China?

The launch process of temozolomide in China

Temozolomide has been launched in China and has entered the Chinese medical insurance system. The drug was developed and produced under license by Merck & Co. It was first approved for marketing by the U.S. Food and Drug Administration (FDA) in 1999, and subsequently passed the recommendation of the European Commission for Patented Medicines (CPMP) in 1997 and was launched in Europe the following year.

After its launch in the Chinese market, temozolomide has greatly enriched domestic treatments for glioblastoma multiforme and anaplastic astrocytoma.

Indications of temozolomide

Temozolomide is mainly used for newly diagnosed glioblastoma multiforme, first in combination with radiotherapy and subsequently as adjuvant therapy. In addition, it is also indicated for glioblastoma multiforme or anaplastic astrocytoma that recurs or progresses after conventional treatment.

These indications make temozolomide one of the key drugs for treating certain types of brain tumors.

Is temozolomide easy to buy?

Regular medical service institutions

Temozolomide has been included in China’s medical insurance, and patients can purchase this drug through formal medical service institutions. There are many generic drugs on the market to choose from, which not only increases patients' medication choices, but also helps promote market competition and reduce drug prices.

Patients should pay attention to the authenticity of drugs when purchasing, pay attention to the production date, and avoid buying fake and inferior drugs.

Selection of online pharmacies

In addition to traditional medical service institutions, some reputable online pharmacies may also provide temozolomide. When purchasing online, you need to confirm the legality of the website and the reliability of the drug source.

Purchasing from a trusted online platform can provide convenience for patients who find it difficult to visit a hospital or pharmacy in person.

Efficacy of temozolomide

Performance in clinical trials

In clinical trials, temozolomide has shown efficacy in newly diagnosed glioblastoma multiforme. The most common adverse reactions include gastrointestinal disturbances such as nausea and vomiting, which are usually mild to moderate, self-limiting or easily controlled by standard antiemetics.

Other common adverse events include fatigue, constipation, headache, etc. Laboratory results show that the incidence of thrombocytopenia and neutropenia is low, with rapid recovery in most cases within 1-2 weeks.

Effects of long-term use

Temozolomide also shows significant efficacy in patients with recurrent or progressive glioblastoma multiforme or anaplastic astrocytoma. Studies have shown that temozolomide can prolong patient survival and improve quality of life.

It is important to note that the efficacy of temozolomide varies between genders, and female patients may require closer monitoring of hematological parameters in some cases.

Use in Special Populations

In elderly patients (age ≥ 65 years), no overall difference in the safety profile of temozolomide was observed and dose adjustment is generally not required. However, for patients with severe hepatic impairment or renal impairment, the recommended dose of temozolomide has not been determined and should be used after careful evaluation.

The safety and effectiveness of temozolomide in pediatric patients have not been fully established and should be used with caution and in accordance with physician guidance.