阿那莫林的功效与作用及注意事项？

The efficacy and effects of Anamorelin mainly include stimulating appetite, increasing weight, improving quality of life, etc. It can treat cachexia patients with unresectable advanced and recurrent non-small cell lung cancer, pancreatic cancer, colorectal cancer, and gastric cancer.

Anamorelin Indications

It is a ghrelin receptor agonist that can be administered orally and is thought to improve cancer cachexia by improving appetite and increasing serum insulin-like growth factor-1. Anamorelin was approved in Japan on December 11, 2020 for the treatment of cancer cachexia in non-small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer.

The mechanism of action of anamorelin

Anamulin is an orally available ghrelin receptor agonist. Ghrelin is a peptide mainly secreted by the stomach. It is an endogenous agonist of type 1a growth hormone receptor. It regulates energy metabolism in the body by promoting growth hormone secretion, increasing appetite, and promoting lipogenesis.

Effects and functions of anamulin

1. Stimulate appetite: Anamorelin stimulates appetite and increases the patient's food intake by acting on the ghrelin receptors in the stomach.

2. Increase weight: By increasing appetite and food intake, anamulin helps improve patients' weight and muscle mass.

3. Improve quality of life: By improving nutritional status and weight, anamulin helps improve the quality of life of cancer patients.

Efficacy of Anamorelin

A phase 2 trial of anamorelin in patients with non-small cell lung cancer and cachexia showed an increase in lean body mass of 1.56 kg as assessed by dual-energy X-ray absorptiometry (DXA), and the treatment group showed significant differences in changes in lean body mass, body weight, and anorexia symptoms compared with the placebo group.

Another study of advanced and unresectable colorectal, gastric, or pancreatic cancer showed an improvement in lean body mass of 1.89 ± 0.36 kg.

Precautions for Anamorelin

1. If no effect is observed 3 weeks after the start of administration, the administration should be stopped. There is no administration experience for more than 12 weeks.

2. Since anamorelin has a sodium channel inhibitory effect, cardiac risks such as prolongation of the QT interval may occur. Therefore, electrocardiograms should be performed regularly before and during administration.

3. Anamorelin may cause blood sugar to rise, so blood sugar levels should be monitored regularly during use.

4. Before starting to use anamorelin and during its administration, liver function tests should be performed regularly to monitor possible liver dysfunction.

Medication Guide

Anamulin is taken orally once a day on an empty stomach, 100 mg each time.

(Note: The above dosage and administration reference are from the Japanese Anamorelin drug instructions. The usage and dosage are for reference only, and the specific needs are subject to medical advice)

Drug use for special groups

1. Use by the elderly: The physiological functions of the elderly may decline. Special care should be taken when using Anamorelin, and the patient's status should be closely observed.

2. Pregnant women: Pregnant women or women who may become pregnant should avoid using anamorelin unless the doctor judges that the benefits of treatment outweigh the risks.

Summary

When using anamorelin, patients should follow the doctor's instructions and undergo necessary examinations regularly. While taking anamorelin, your doctor should be informed of all medications you are taking to avoid potential drug interactions.

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