阿那莫林是什么药物？治疗癌症恶病质效果好吗

Cancer cachexia is one of the main causes of death in patients with advanced cancer. More than 80% of patients with advanced cancer will have cachexia. Once it occurs, it may affect the implementation of the treatment plan, reduce the sensitivity of chemotherapy, increase the difficulty of treatment and the occurrence of related treatment complications, seriously affect the quality of life of patients, and shorten the survival period. Anamorelin is approved to treat cancer cachexia, but what drug is it? Is it effective to treat cancer cachexia?

Anamorelin indications

Anamorelin is a novel, oral, selective ghrelin receptor agonist. Ghrelin is an endogenous peptide mainly secreted by the stomach. After binding to its receptor, it stimulates multiple pathways to positively regulate body weight, muscle mass, appetite and metabolism. Anamorelin can be used to treat cancer cachexia in patients with non-small cell lung cancer, gastric cancer, pancreatic cancer, colorectal cancer and other malignant tumors.

Anamorelin therapeutic effects

Anamorelin is the first drug to treat cancer cachexia. Clinical data shows that anamorelin can increase body weight, muscle mass, and appetite in patients with cancer cachexia. The launch of anamorelin will provide a new treatment option for patients with cancer cachexia who have no treatment options and help improve the quality of life of such patients.

Anamorelin has been approved for marketing in Japan. The approval was mainly based on the results of 2 clinical studies conducted in Japan on patients with cancer cachexia (ONO-7643-04 study, ONO-7643-05 study). The first experimental result was that after treatment with anamorelin, 63% of patients maintained and gained weight, and their appetite also improved. The results of the second experiment were that patients in the anamorelin-Adlumiz group gained an average of 1.38 kg in weight, while patients in the placebo group lost an average of 0.17 kg. It can be seen from the experimental results that anamorelin has a significant effect in treating cancer cachexia. It can improve the patient's appetite and weight, improve the patient's disease progression, and have a positive effect on the patient's condition.

Anamorelin Precautions

Treatment with anamorelin may cause harm to the fetus. By injecting ghrelin or ghrelin simulation into mice, delayed embryogenesis, low fetal weight, decreased pregnancy rate, and reduced number of fetuses were found. Therefore, it is not recommended for pregnant women to use this drug for treatment. If the patient is pregnant, please inform the doctor before receiving this drug, and the doctor will adjust the medication plan.

Treatment with anamorelin may cause hyperglycemia, so patients should have their blood glucose and urine glucose measured regularly before starting treatment with this drug and during administration.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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